Replication fork collapse at replication terminator sequences
نویسندگان
چکیده
منابع مشابه
Preserving the Replication Fork in Response to Nucleotide Starvation: Evading the Replication Fork Collapse Point
Replication fork progression is blocked by a variety impediments including DNA damage, aberrant DNA structures, or nucleotide depletion [1-3]. The response to replication fork stalling varies according the type of replication inhibition, the number of stalled forks and the duration of the treatment [3-7]. Stalled replication forks are at increased risk for DNA damage, which can lead to mutation...
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The replication terminator protein (RTP) of Bacillus subtilis interacts with its cognate DNA terminators to cause replication fork arrest, thereby ensuring that the forks approaching one another at the conclusion of a round of replication meet within a restricted terminus region. A similar situation exists in Escherichia coli, but it appears that the fork-arrest systems in these two organisms h...
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The DNA damage response kinase ataxia telangiectasia and Rad3-related (ATR) coordinates much of the cellular response to replication stress. The exact mechanisms by which ATR regulates DNA synthesis in conditions of replication stress are largely unknown, but this activity is critical for the viability and proliferation of cancer cells, making ATR a potential therapeutic target. Here we use sel...
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Accurate and complete replication of the genome in every cell division is a prerequisite of genomic stability. Thus, both prokaryotic and eukaryotic replication forks are extremely precise and robust molecular machines that have evolved to be up to the task. However, it has recently become clear that the replication fork is more of a hurdler than a runner: it must overcome various obstacles pre...
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ژورنال
عنوان ژورنال: The EMBO Journal
سال: 2002
ISSN: 1460-2075
DOI: 10.1093/emboj/cdf369